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MTHFR – Is it Connected to Infertility? Mood Issues? High Homocysteine?

Yes, MTHFR is connected to many functions in the body. It is an enzyme that converts folate (B9) to its active form. 
Dr. Amy Meyers wrote,”Every single cell and tissue in your body experiences methylation. Methylation protects your body by repairing damaged cells, optimizing DNA cell function, processing toxins and hormones, metabolizing B vitamins, and regulating neurotransmitters such as dopamine, serotonin and norepinephrine, which control mood, behavior, sleep and your overall mental health.

One of the most important tasks methylation performs is turning homocysteine into methionine. Methionine, is a veritable powerhouse – building proteins, repairing and regenerating cells, detoxifying, controlling inflammation, and helping your liver to process fats, among many other functions.”

What is it? How do we supplement?

I did a podcast on the topic, HERE, with Dr Amy Neuzil, ND.

Dr Amy said, “MTHFR mutation is a huge factor in physical and mental health but we’re still learning the basics because it’s all very new research so the best dose of methylfolate for MTHFR mutants isn’t really a straight answer.

The good news is there are lots of ways to read your body and to learn the best dose of methylfolate for YOU. If you’re a little fuzzy on this whole MTHFR thing, then check out this Understand the basics


MTHFR mutations can be the  cause of fertility issues, mood problems, depression, anxiety, increased risk for heart disease, problems detoxifying and more.


Get tested!

Supplement with active form of FOLATE (5MTHF).

We use a L-5MTHF B complex with extra high dose 5MTHF folate.

  • Klaire Labs B Complex Plus. Start with the B Complex alone for a week or two, with 400mcg of Folate. Let your system get used to that. Then add more 5MTHF
  • Thorne 5-MTHF 5mg (recommended by Bill’s doctor) or proceed more slowly so you don’t flood your system too fast (which can make some people start detoxing too fast). Dr. Amy says (in the linked podcast) go slow, especially the more copies you have of the gene defect. Start with Thorne 5-MTHF 1mg. Be on 1mg for one week, then go to 2mg, for a week. Every week go up 1mg until you are at 5mg and stay there. 

Also supplement with quality B12. We use sublingual Perque Active B12

Take NAC, n-acetylcysteine, another helpful nutrient.


Be sure to make these supplements part of daily life!

Learn more.