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Antiviral Oral and Nasal Spray using Betadine Iodine

An antiviral antiseptic gargle and nasal spray may help healthy people avoid virus infection. It is not a cure but provides a line of protection. Antiviral antiseptic is intended for use by healthy adults. Forward this information to your primary care provider if you have concerns. This is an antiseptic and can be used in or on the body as shown below in a diluted form.

This is not a drink. The gargle or the nasal spray is spit out after application.

What is Povidone Iodine

Povidone Iodine (PVP-I) is a liquid that is available as a 10% concentration. Typically Povidone Iodine comes in 8oz or 32oz bottles.

Is Betadine the same thing as Povidone Iodine?

Betadine is a brand name of Povidone Iodine, 10%. There will be some stabilizers added to Povidone Iodine and Betadine Solution.

Directions for Preparing a diluted Povidone Iodine Gargle and Nasal Spray

10% Betadine or Povidone Iodine must be diluted before use.

Buy three items, no prescription needed

  1. Povidone Iodine, 10% or Betadine
  2. Nasal spray atomizer
  3. Distilled or Purified Water

Where to buy Povidone Iodine and Nasal Spray Atomizer


In the past it has been easy to buy PVP-I at the local drug store or on-line but the availability is decreasing daily. Look for Betadine Solution, 10% at your local store, check Amazon, and check WalMart.com. I bought three 8oz bottles from Walmart for about $25 (about $1/ounce).


Nasal spray atomizer. Empty glass bottles, 6 pack HERE


How to dilute Povidone Iodine or Betadine for gargle or nasal spray


Type of water. Dilute the PVP-I or Betadine with distilled water, or purified filtered water (I use water filtered by a Berkey or you may purchased bottled spring water or distilled water).

Do not tap water. Tap water in a nasal application can cause a sinus infection according to Dr. Jeffrey Dorfman.

Prepare the dilution in a clean container such as a quart glass jar.

  • 1 ounce of povidone iodine
  • 19 ounces of distilled or purified water

How to use Diluted Povidone Iodine for gargle or nasal spray

  • Pour diluted liquid into a nasal spray bottle. Use two sprays in each nostril. Squirt the diluted spray up nose, sniff back to the back of the throat and spit out.
  • For the oral gargle use a few teaspoons of the diluted liquid, gargle 30 seconds, spit it out.
  • Do not eat or drink for 30-60 minutes after using.
  • Use gargle and nasal sprays every three hours up to four times a day.

Is it safe to use povidone iodine gargle and nasal spray?

Like many early treatment and prevention options, main stream media will put out a lot of scary articles. I trust physicians who are advocating for affordable, effective and simple early treatment options.


Dr. Peter A. McCullough

Dr. Peter A. McCullough shared on a podcast and elsewhere the use of PVP-I or Betadine after close contact with people as a prevention method. “The SARS-CoV-2 virus is transmitted in the air and settles in the nose, and multiplies for days before it invades the body. When sick with nasal congestion, headache, fever, and body aches, the source of symptoms is the virus in the nose.

The virus must be killed in the nasal cavity at least twice a day after coming back home for prevention and up to every four hours during active treatment. This is very important with the Omicron variant, which multiplies 70 times faster than the prior strains of the virus.

Early treatment using this approach is associated with a 71% improvement, as shown in the figure.

Squirt it up the nose, sniff it back to the back of the throat and spit it out.

Dr. McCullough uses 2 tsp Betadine or PVP-I, mixed in a jar with 6 oz of distilled or purified water, squirt two sprays up each nostril, sniff back to the back of the throat and spit out. Then gargle with a few teaspoons of the solution for 30 sec. Spit it out. Do not swallow. If iodine allergic or intolerant, can substitute hydrogen peroxide. (Note: 2 tsp (.33oz) in 6 oz purified water is about the same dilution as 1 oz in 19 oz water).


Association of American Physicians support the use of diluted Povidone Iodine as a gargle or nasal spray.

TUCSON, Ariz., Oct. 13, 2021 (GLOBE NEWSWIRE) — In response to public interest in the use of a common disinfectant, povidone-iodine (PVP-I or Betadine™), to prevent or ameliorate COVID-19, the Association of American Physicians and Surgeons (AAPS) has released a statement concerning the potential benefit and safe usage of this modality.

The AAPS statement notes that seven studies have shown efficacy in early treatment or pre-exposure prophylaxis. For example:

  • Bidra et al. showed rapid inactivation of SARS-CoV-2 when povidone-iodine (PVP-I) was used as an oral rinse. 
  • Frank et al. showed that dilute PVP-I can be safely used as an oral rinse or nasal spray. 
  • Guenezan et al. showed reduced viral load in a randomized controlled trial. 
  • Choudhury et al. used Betadine as acute therapy for incipient COVID-19 in a randomized controlled trial that showed significantly lower death and hospitalization rate.

All the studies used dilute Betadine as an oral rinse, gargle, or nasal spray.

AAPS suggests a 20-to-1 dilution (2 tsp of Betadine to 6 oz. of distilled or purified water) and provides a link to detailed videotaped instructions.

AAPS cautions that while one should never drink substances intended to be used on surfaces or skin, and one should spit out the oral rinse or gargle, an adult would need to drink several quarts of undiluted Betadine to do serious immediate harm. Thus, AAPS concludes that when used as directed, Betadine is safe and potentially of help.

The Association of American Physicians and Surgeons (AAPS) is a national organization representing physicians in all specialties since 1943.


Dr. Samantha Frank

Newsmax reported: Dr. Samantha Frank of the University of Connecticut School of Medicine says that iodine-based nasal antiseptics have been used to treat other conditions, such as inflammation of the sinuses and nasal cavity, for years.

“They are not new or unique to COVID-19, but fortunately inactivate SARS-CoV-2 as well,” she said. According to Verywell Health, PVP-1 also kills MRSA, SARS-CoV, influenza H1N1, and the rotavirus.

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