GLP-1 Probiotic Protocol for Low Akkermansia Levels
- Akkermansia muciniphila is a keystone strain for gut health as it strengthens the gut lining, supports GLP-1 production, and improves digestive health.
- Akkermansia is an important probiotic strain that plays a role in boosting GLP-1 Production.
- GLP-1 Probiotic naturally boosts GLP-1 production. It does not contain GLP-1 and is not a GLP-1 agonist drug.
Read about GLP-1 Probiotic here: GLP-1 Probiotic naturally boosts GLP-1 production.
It does not contain GLP-1 and is not a GLP-1 agonist drug.
GLP-1 Probiotic, take once a day.
Probiotic Blend (500 million AFU) … 20mg
Clostridium butyricum WB-STR-0006
Akkermansia muciniphila WB-STR-0001
Bifidobacterium infantis
Chicory Inulin … 211mg
Addressing low levels of Akkermansia muciniphila
Developed in collaboration with Dr. Kara Fitzgerald, ND, IFMCP
Disclaimer: The Pendulum team has created these protocols in collaboration with practitioners to help healthcare partners make decisions when building treatment plans.
When using this protocol, you understand and accept that the recommendations in the protocol are for educational guidance only. This protocol is not a substitute for medical advice, and is not intended to diagnose, treat or prevent any medical disease.
- Please consult with your qualified medical professional to determine if this protocol is appropriate for you.
Description
Akkermansia muciniphila has appeared in over 3,000 scientific publications, and abundance has been associated with maintaining intestinal integrity. The primary function of Akkermansia muciniphila is to support healthy mucin layer turnover in the intestines, and thus strengthen the intestinal lining. Furthermore, Akkermansia muciniphila releases short chain fatty acids such as acetate and propionate, that support the abundance and diversity of other health-promoting microorganisms in the gut. (1)
Metabolic dysfunction stems in part from an increase in permeability of the gut barrier, which separates contents of the gut lumen from peripheral circulation. When the gut barrier becomes too permeable, levels of circulating lipopolysaccharide (LPS) from Gram-negative bacteria increase, activating pro-inflammatory cytokines and leading to chronic low-grade inflammation (2) which is associated with both weight gain and higher fasting glucose levels. (3)
A major protective factor against gut barrier permeability is the layer of mucus coating the inner wall of the digestive tract, which provides a home for certain mucin-loving bacteria such as Akkermansia muciniphila. When Akkermansia muciniphila consumes mucin, the host compensates by continuing to produce more mucins, helping replenish this protective layer and thus enhancing the integrity of the intestinal barrier. (4)
Supplement and Dietary Plan
- Supplement with Akkermansia: 1 capsule, once daily with food
- For patients with undetectable levels of Akkermansia, a higher replenishment dose for 3-6 months may be necessary to repopulate the gut
- Encourage intake of polyphenols such as pomegranate, green tea, and grape seed (5)
- Supplement as necessary with Pendulum’s Polyphenol Booster to boost Akkermansia which may further enhance the benefits
- Encourage intake of prebiotic dietary fibers such as onion, chicory, garlic, asparagus, banana, and artichokes (6)
- Consider supplementation with DHA/EPA to promote Akkermansia abundance (7)
- Consider the possibility of intestinal permeability and/or damaged mucosa especially with other microbiome test findings (low IgA, elevated zonulin)
References
- (1) Geerlings SY, Kostopoulos I, De Vos WM, Belzer C. Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How? Microorganisms. 2018;6(3):75. doi:10.3390/microorganisms6030075
- (2) Cani, Patrice D et al. “Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.” Diabetes vol. 57,6 (2008): 1470-81. doi:10.2337/db07-1403
- (3) Cani, Patrice D et al. “Metabolic endotoxemia initiates obesity and insulin resistance.” Diabetes vol. 56,7 (2007): 1761-72. doi:10.2337/db06-1491
- (4) Liu MJ, Yang JY, Yan ZH, et al. Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases. Clin Nutr. 2022 Oct;41(10):2333-2344. doi: 10.1016/j.clnu.2022.08.029. Epub 2022 Sep 3. PMID: 36113229
- (5) Anhê FF, Pilon G, Roy D, Desjardins Y, Levy E, Marette A. TriggeringAkkermansiawith dietary polyphenols: A new weapon to combat the metabolic syndrome? Gut Microbes. 2016;7(2):146-153. doi:10.1080/19490976.2016.1142036
- (6) Zhou K. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. Journal of Functional Foods. 2017;33:194-201. doi:10.1016/j.jff.2017.03.045
(7) Costantini L, Molinari R, Farinon B, Merendino N. Impact of omega-3 fatty acids on the gut microbiota. International Journal of Molecular Sciences. 2017;18(12):2645. doi:10.3390/ijms18122645
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