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Everyone Needs to Know: MTHFR

Do you have the MTHFR gene mutation? 40-50% of us do!

Scroll down to listen to my podcast with Dr Amy Neuzil.

Do you know if you have MTHFR genetic variant?

YOU need to know your MTHFR status! 

It means you do not convert certain B vitamins into the active form so you may end up with low folate and low B12 etc. Sometimes we also see a high B12 level for people who have the MTHFR genetic variant.

This is an important enzyme in the body, and if you have low levels of MTHFR activity – so much goes wonky! 

Good news, there are many things you can do to address this with lifestyle, food, supplements.

Can MTHFR cause High Vitamin B12 – or Low B12?

Yes, a low B12 can indicate MTHFR problems. [source] Some symptoms of folate deficiency caused by MTHFR can be an important indicator of a B12 deficiency such as:

  • Anemia
  • Eczema
  • Cracked lips
  • Prematurely greying hair
  • Anxiety
  • Tension
  • Poor memory
  • Lack of energy
  • Poor appetite
  • Stomach pains

MTHFR can cause high B12 on a blood test result, this is because of lower production of folate which means that more B12 may not have enough folate to work with, which leads to higher B12 levels. 

“Higher B12 levels can also be the result of inhibitors that interfere with the MTHFR process and therefore support MTHFR high B12. High B12 MTHFR problems are very common, MTHFR and high B12 often also result from MTHFR b12 supplements that are used in excess.” [source]

Taking high quality B vitamins won’t help if they aren’t the right form for you. You will need to take methylated B vitamins.

40-50%+ people have this genetic situation going on and it may be why there are higher risk/incidence of

  • Fertility problems
  • Recurrent miscarriages
  • Inflammation
  • Mood issues, long history of anxiety and depression
  • Foggy thinking
  • High homocysteine levels in the blood- increasing your risk for heart disease, stroke 
  • Macular Degeneration
  • Cancer
  • Colon cancer
  • Inability to process alcohol like most people and a tendency to be alcohol-addicted
  • Low pain tolerance
  • Hormone processing problems, inability to clear estrogen
  • Unusual response to drugs (nitrous oxide, antidepressants, chemotherapy drugs)
  • Migraines
  • Alzheimer’s Disease
  • Fatigue, light headed, forgetful (signs of low folate)
  • Long history of digestive issues
  • Impaired ability to detox – suffer from mold toxicity more easily
  • Sensitive to smells
  • Chemical sensitivity
  • MS
  • Autoimmune like Hashimoto’s Thyroiditis
  • Autism
  • Hard time breaking down histamine

Supplements Needed

  • Methyl B Complex or Active B Complex, one capsule twice a day.
  • Activated B-12 Guard™ 2000 mcg, sublingual, once a day.
  • 5-MTHF 1 mg 60 caps,. Begin with 1 mg for a few days, then 2mg, and slowly work up to 5mg. Then switch to the 5mg capsule.

TEST: Everyone can order the 23andMe test.

Get your 23andMe results then take it the next step (you will download raw data from your account with 23andMe then upload the data to to find out about MTHFR and other variants.

Listen to my Podcast with Dr. Amy Neuzil