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Specialized Pro-Resolving Mediators

“SPMs are poised to be the most effective inflammation treatment of the 21st century. They resolve inflammation very effectively, without compromising the immune response and without risky side effects.” [source]

SPMs are useful for a wide variety of chronic inflammatory conditions where inflammation is unresolved. These include: asthma, arthritis, cancer, cardiovascular disease, COPD, atherosclerosis, leaky gut syndrome, irritable bowel disease, ulcerative colitis, malabsorption, obesity, Crohn’s Disease, diabetes, fibromyalgia, autoimmune conditions, Alzheimer’s and neurodegenerative disease. [source] [source][source]

The Role of Specialized Pro Resolving Mediators in Health

Video presentation by Dr. Melvyn Grovit, DPM, MS, CNS

Also see the original paper by Dr. Charles Serhan, published in 2017, Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. FASEB J. 2017 Jan 13;31(4):1273–1288. doi: 10.1096/fj.201601222R


Specialized Pro-Resolving Mediators (SPMs) can eliminate inflammation and take a condition to its full resolution. It is a miracle nutraceutical.

— Dr. Melvyn Grovit


We can make SPMs endogenously. SPMs are produced in the body primarily from the metabolism of Omega-3 and Omega-6 fatty acids.

There are four classes of SPMs:

  • Lipoxins
  • Resolvins
  • Protectins
  • Maresins

SPMs are derived from fish oil.

The amount of SPM that is in fish oil is the amount that you would find on the head of a pin.

If you take the SPM out of fish oil, the only function of fish oil at that point is for cellular membrane—keeping them flexible.

We take fish oil capsules hoping that they will reduce inflammation. We can have a better anti-inflammatory result by using SPMs. SPM, a concentrate of what is in fish oil, absolutely eliminates the inflammation.


We need inflammation but we do not need excessive inflammation.

  • SPMs counter pro-inflammatory activity.
  • SPMs limit tissue damage.
  • SPMs actively promote resolution of inflammation.

SPMs actively promote inflammation resolution.

  • Enhance macrophage phagocytosis (clears up cellular debris)
  • Shorten time to resolution
  • Increase production of anti-inflammatory mediators
  • Increase the killing and clearance of microbes (virus, yeast, bacteria)
  • Enhance tissue regeneration

The Value of Supplementing and Recommended Dosage

“A more direct and targeted way to raise SPMs levels is to supplement with them directly. These supplements are made from fish oil using a patented fractionation process to create an SPMs-enriched product. Recent research has shown that daily dosing with two to six soft gels over six weeks produces reductions in standard inflammation blood markers such as hs-CRP, interleukins, fibrinogen, and TNF-alpha.

“Because SPMs are naturally produced as a normal part of resolving inflammation, the supplements don’t suppress immunity. This makes them much safer than anti-inflammatory drugs such as glucocorticoids or methotrexate or even aspirin. SPMs supplements can be taken indefinitely. They have no known side effects or interactions with other supplements or drugs.

“The usual dosing for SPMs is three capsules two times daily for during the acute inflammation stage. As inflammation becomes subacute, the dosage can be reduced to two capsules twice daily. For ongoing mild inflammation and for maintenance, the suggested dosage is two capsules once daily.” [source]


SPM Active, Metagenics (save 15%)

Description

Renews the body’s natural ability to alleviate soreness and joint discomfort. SPM Active® is formulated to target root causes of soreness by supporting the body’s natural ability to soothe and minimize discomfort. Designed to help with soreness intensity in two weeks. Take daily for maximum benefit.

Amount Per Capsule

Active Fractionated Marine Lipid Concentrate† … 500mg

SPM content standardized to
18-hydroxy-eicosapentaenoic acid (18-HEPE)
17-hydroxy-docosahexaenoic acid (17-HDHA) and 
14-hydroxy-docosahexaenoic acid (14-HDHA)

Other Ingredients: Fractionated marine lipid concentrate [fish oil (anchovy, sardine, andmackerel) and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin,and water), and silica.


SPM Supreme, Designs for Health (save 15%)

SPM Supreme™ is a combination of three highly potent “specialized pro-resolving mediators” designed to help support the body’s natural ability to respond to physical challenges and “resolve” the initial steps in the natural inflammatory process. The “resolution” of a healthy inflammatory response is an active process controlled by these unique metabolites.

Amount Per capsule

Active Fractionated Marine Lipid Concentrate† … 300mg

18-hydroxy-eicosapentaenoic acid (18-HEPE)
17-hydroxy-docosahexaenoic acid (17-HDHA) and 
14-hydroxy-docosahexaenoic acid (14-HDHA)

Other Ingredients: Olive oil, bovine gelatin, glycerine, purified water, natural lemon flavor, DeltaGold® tocotrienols.


Pro-Resolving Mediators, Life Extension (save 15%)

Specialized pro-resolving mediators (SPMs) help maintain the body’s healthy post-inflammatory response to support whole body health. This innovative formula promotes the natural clearing of cellular debris, helps maintain a healthy relationship with inflammatory factors to promote whole body health, and supports healthy tissue rejuvenation.

Amount Per capsule

Marine Lipid Concentrate … 500mg

18-hydroxy-eicosapentaenoic acid (18-HEPE)
17-hydroxy-docosahexaenoic acid (17-HDHA) and 
14-hydroxy-docosahexaenoic acid (14-HDHA)

Other Ingredients: Highly refined marine oil concentrate (squid, anchovy, sardine, herring, mackerel), gelatin, olive oil, glycerin, purified water, lemon flavor, mixed tocopherols.


SPM Testimonies

“I had a terrible pinched nerve underneath my shoulder blade. No matter what I did, it would not get better. My naturopath recommended this product. Within a few days, along with some magnesium taurate, I was able to move my arm without pain and the tingling went away. It was amazing and after a week of taking it, I am back to myself. I highly recommend this product (SPM Active).” – LB

“Our doctor told us this supplement doesn’t just reduce inflammation; it resolves it. SPM Active has reduced my daughter’s post-COVID tics by 95%! We are amazed at how quickly and effectively this supplement has improved her health. I was sceptical that a supplement could have an impact on her sudden onset and extreme tic disorder after having the virus, but it totally worked when no other medicine reduced her constant tics. Amazing!” -Susie

“When I take this product twice a day, it’s like magic. I wake up and my hip pain is 95% gone.” – S. Lee

“I suffer from a vascular inflammatory disease (Takayasu’s arteritis) and this (SPM Supreme) has stopped a flare up in its tracks. Way safer than prednisone.” -S. Kauffman

“I’m 56yrs old. After taking for one month all pain in my joints and back are completely gone. Also I had a nagging dry cough from having Covid last year. I coughed all the time. It also is gone. I’ve tried everything and this is the real deal. I will not ever go without my SPM.” -John C.



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