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Butyrate May Help: Gut Health, IBS, Constipation, Post-Antibiotic Gut Issues

What is Butyrate


Butyrate (pronounced “byoo-ter-ate”) is produced in the colon through bacterial fermentation using dietary fibers and starch as sources. Butyrate-producing microbes are bacteria belonging to the Firmicutes phylum.

Butyrate has anti-inflammatory properties and affects intestinal mucosal immunity. Sodium butyrate (NaB) has a wide range of beneficial properties/activities. NaB has been investigated in case of several diseases, such as inflammatory bowel diseases (IBDs), non-alcoholic fatty liver disease (NAFLD), and obesity.

During the last several years, an increasing interest in the effect of NaB usage in the context of colorectal cancer has been observed. Using of NaB may be a promising strategy for colorectal cancer patients. Butyrate can induce the apoptosis (cell death) of colorectal cancer cells. It provides anti-tumor effects via several molecular mechanisms.

Butyrate is an effective gut health supplement with full-body benefits.

  • Critical in repairing the lining of the gut and the health of cells within it.
  • Supports a healthy inflammation response to protect the body from disease while improving immune function.

Butyrate Benefits IBS

  • One study followed 66 adults with irritable bowel syndrome (IBS). The participants took a daily dose of sodium butyrate for 12 weeks. “After 4 weeks there was a significant decrease of pain during defaecation in the Butyrate group which extended to improvement of urgency and bowel habit at 12 weeks.” [source]
  • Another study involving a total of 2990 adults showed a statistically significant improvement in severity of abdominal pain. In addition there was a significant decrease in flatulence, diarrhea, constipation, urgent pressure for bowel movements, nausea, and vomiting. Most of the respondents (93.9%) declared that they would continue the therapy and 88.9% would recommend using sodium butyrate to other IBS patients. [source]

Butyrate repairs the damage that pesticides, toxins, processed foods, drugs, etc. have done to the lining of the gut. Butyrate helps to heal the gut lining and promotes healthy DNA to support genetic function against damage, which may lead to disease.

Suggested Use

  • 1-2 capsules with food, unless otherwise suggested by your Healthcare Professional.
  • It is recommended to take Butyrate for a minimum of six weeks to realize the full effects.
  • You can take butyrate any time of day. Some people find that taking butyrate before bed helps them have better digestion the following morning. Some people prefer to take butyrate in the morning to set them up for the day ahead. Experiment with what works best for you.

What are people reporting after using Butyrate?

“Amazing stuff, I’ve had decades of constipation and now I no longer deal with it. I’m quite impressed how it works with your body. I love this product and will continue to use forever.” ~Sonya P.

“Settled my gut after a stay in the hospital with massive antibiotic treatment. Surprised and pleased.” ~ Carl H.

“The butyrate is helping to heal my IBS symptoms very quickly. Within a few days I felt much better.i use both kinds and alternate them every 3-4 weeks.” ~Lynn F.

“Love this supplement! It’s really improved my gut health, which has in turn improved my energy levels & general well being. Highly recommend!” ~Kerry G.

“As a person who has struggled with gut health since my teens this has started to change my life. I’ve had IBS for as long as I can remember and would have to go urgently. If there’s one thing I know it’s where to find the cleanest restroom on the road or out on the town, lol. Butyrate has changed that and has made me more regular, less explosive, less gut pressure, and less upset stomach. Highly encourage you to give it a go!” ~Guy W.

“If I had to chose one supplement for autoimmunity this would be it! Such a sure way to get the prebiotics needed for gut health and tight junctions….improves my psoriasis every time I take it. Improves autoimmune symptoms in anyone I recommend it to. Took it recently daily when taking an antibiotic and got no bloating or digestive discomfort after the antibiotic. It’s a fantastic supplement- I even associate the smell with healing now so don’t mind it at all.” ~Melissa R.

Butyrate Supplements – Specially formulated to:

  • Support gut health
  • Promote detoxification
  • Maintain proper pH levels in the colon
  • Reduce inflammation
  • Promote healthy DNA function
  • Support healthy blood sugar regulation
  • Butyrate serves to close tight junctions and prevent the dysbiosis commonly known as leaky gut

I recommend BodyBio Butyrate. Quality matters! There are no fillers or additives. There is no way to achieve the powerful benefits of butyrate without its distinctive, fermented scent. This means it’s premium quality and ready to work. BodyBio’s Butyrate is made with all natural ingredients and free of wheat, gluten, yeast, corn, soy, dairy, artificial colors, and resins.

Two unique formulations: Calcium/Magnesium Butyrate and Sodium Butyrate.

Both options provide effective gut health supplementation, which supports digestive and brain health, while also protecting against disease.

What’s the difference between Sodium Butyrate and Calcium/Magnesium Butyrate?

The only difference between the two forms of BodyBio Butyrate is the minerals used to create the butyrate salt: either sodium + butyric acid, or calcium + magnesium + butyric acid. Other than that there is no difference between the two. The company offers two options because most scientific research on butyrate is conducted with sodium butyrate. This is what we recommend for most people. However, some people wish to avoid any extra sodium intake, so they created the calcium/magnesium version as an alternative. Both are equally effective.

Sodium Butyrate – The form recommended for most people

Calcium/Magnesium Butyrate – for those who wish to avoid any extra sodium intake

What to Expect when Taking Butyrate

0-2 Weeks

Colonocytes (gut cells) are energized. Some people notice a difference within the first day of taking butyrate while others notice improvement in their digestive health within the first week or so. As butyrate levels build up over time, you will notice more positive changes in digestion and gut health.

2-4 Weeks

Digestive function continues to improve, leaky gut resolves, healthy gut flora is reestablished, and blood sugar peaks and valleys become more like gentle, rolling hills. All while keeping you regular with well-formed stools.*

4 Weeks+

Gradually builds a healthy gut structure over time, supporting your immune resistance, subsiding systemic inflammation in the gut, banishing brain fog, helping with weight regulation, and improving your overall health.


Is Butyrate enterically coated? How do I know it will reach the gut?

The capsules of butyrate are vegetarian, made from plant cellulose. The butyrate powder within is enterically coated. We want to make sure that butyrate survives exposure to stomach acid and gets to the colon, where it will be most effective in supporting gut cells. Here, an approach has been devised to tackle the challenge of butyrate delivery—coating with a vegetable fat, commonly called a medium-chain triglyceride. The reasoning behind this is that a significant part of the butyrate will be released only when lipase (fat digesting enzyme) is secreted in the duodenum, the first part of the small intestine.

Can I take more than two capsules a day?

Yes, many people take multiple doses, in the morning and evening, or even 1-2 caps with each meal. It depends on your gut and how you feel with butyrate. If you are not seeing improvement in your gut health at two caps per day, we recommend increasing your dose by one cap until you do. You may wish to split these doses throughout the day, or take them all at once — listen to your gut. When in doubt, consult your practitioner for their advice regarding dosage and timing.

Is it supposed to smell?

Yes, and we do not use any additives or fillers to mask the scent. Butyrate is quite infamous for its scent because it is a molecule naturally produced by the body to feed colon cells. Certain gut bacteria create butyrate via a fermentation process, so, naturally, it doesn’t smell good. Substances sometimes added to butyrate in order to control its aroma interfere with butyrate’s benefits.

Is butyrate similar to a probiotic?

No, butyrate is NOT bacteria but it is a short-chain fatty acid (SCFA). It is made in the lower colon by probiotic bacteria and taken up by the colonocytes, the cells that line the colon. It then becomes an important food for those cells. A lack of good bacteria in the colon, due to antibiotic use for example, can lead to an insufficient supply of butyrate. See below for a probiotic suggestion.

Option: Start with a Six Day Colon Cleanse then add Butyrate and Probiotics

The Colon Cleanse Program is an oxygen-based intestinal cleanse that uses Oxy-Powder and Latero-Flora (15% discount, click on photos above) to gently cleanse and rejuvenate the digestive tract so you can live more comfortably. Read more here.

Health Benefits of the Colon Cleanse Program

The Colon Cleanse Program is a one-two approach. First, Oxy-Powder uses the power of oxygen to break down impacted waste and cleanse the digestive tract. This sets the stage for Latero-Flora to supply probiotics that strengthen your gut and support detoxification.

After the colon cleanse try adding Butyrate. It is recommended to take Butyrate for a minimum of six weeks to realize the full effects.

Add a Probiotic

DigestaGuard Forte 10 Benefit: 

  • Protects the digestive track even when under assault in turn defending against infection and ill health.
  • Provides 7.5 billion peak-harvested 10-strain microorganisms per capsule that support comprehensive intestinal health.

PERQUE Digesta Guard Forte 10 is essential for individuals who take antibiotics. These medications wipe out good as well as bad bacteria, leading to complications, such as yeast infections, maldigestion, constipation, or diarrhea and nausea.

Digesta Guard Forte 10 effectively rehabilitates the digestive system by restoring the body’s healthy, digestive organisms and clearing out toxins in the intestines. As individuals age, digestive malfunctions become more common. Breakdowns in the digestive tract are linked with antibiotic use, unhealthy diet, food allergies, heartburn, gastritis, ulcers, hemorrhoids, flatulence, and constipation.

PERQUE Digesta Guard Forte 10 is a probiotic supplement that actually replaces bad bugs with ten beneficial bacteria. It thereby improves digestion and wards off dietary toxins, such as pesticide residues, hormones in foods, and toxic metals like lead or mercury.

Directions: Take one (1) to six (6) capsules daily as directed by your health professional. Capsule may be opened and sprinkled on food. 

Serving Size: One Capsule

Amount Per Serving
Alive, energized probiotic organisms … 5 billion
B. bifidum R0071 … 500 million
B. breve R0070 … 200 million
B. longum R0175 … 600 million
L. acidophilus R0418 … 1000 million
L. casei R0215 … 400 million
L. paracasei L26 … 400 million
L. plantarum R1012 … 200 million
L. rhamnosus R0011 … 500 million
Lc. lactis ssp. lactis R1058 … 1000 million
S. thermophilus R0083 … 200 million
Vitamin C … 1.36mg (100% l-ascorbate, fully reduced, corn free)
Magnesium … 3.4mg(as C16 and C18 alkyls from whole, untreated palm fruit and leaf)
Maltodextrin … 358mg
Vegetable capsule … 75mg

Read more about DigestaGuard here.