NAC N-Acetyl-L-Cysteine
NAC is a precursor needed for the body to make glutathione, a major anti-oxidant. NAC also helps the liver detoxify.
Take 500mg or 600 mg NAC daily. When sick take that dosage three times a day.
Klaire Item #: KL2555 on Wellevate (15% discount when you register here).This derivative of the amino acid cysteine is often used as the preferred substrate for intracellular glutathione synthesis. It also assists detoxification, provides cellular antioxidant protection, and is much safer than cysteine.
Thorne Item #T60029 on Wellevate. 15% discount when you register here. As well as having it’s own antioxidant activity, NAC stimulates the synthesis and activity of glutathione, the master antioxidant. NAC effectively supports liver detoxification. NAC also promotes the thinning of mucus in the lungs, making it easier to clear when coughing which supports respiratory health, as well as supports clear, healthy sinuses.
Study: COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has been demonstrated to occur in COVID-19 patients.
N- Acetyl-L-cysteine (NAC) is a precursor of reduced glutathione (GSH).
Based on a broad range of antioxidant and anti-inflammatory mechanisms, which are herein reviewed, the oral administration of NAC is likely to attenuate the risk of developing COVID-19, as it was previously demonstrated for influenza and influenza-like illnesses.
Study: NAC has two principal activities: NAC exhibits a mucolytic effect due to its free sulfhydryl group which reduces disulfide bonds in the cross-linked mucus glycoproteins matrix, thereby lowering mucus viscosity; and NAC is a potent antioxidant with a direct effect on certain oxidant species, an indirect effect because it acts as a precursor to cysteine (required for glutathione synthesis), and the ability to restore thiol pools which in turn regulate redox state.
Considering these properties, we hypothesize that NAC could negatively affect SARS-CoV-2 activity for the following reasons:
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